XCIR is the initiator for the epigenetic cascade in tissue
Tight Epigenetic Control Starts Here
Ocis Biotechnology is a regenerative medicine company that specializes in epigenetic modulation for tissue regeneration, repair and renewal. XCIR, ( pronounced exsir), is Ocis's patented molecular therapy. XCIR is an unprecedented advance in epigenetic control of all tissue cell types. There are four molecular mechnisms that XCIR influences invivo and invitro; epigentic regulation, redox signaling and ECM/collagen homeostasis and a self assembling nano matrix all in one. XCIR is one platform to advance any research program in regenerative medicine.
PROVIDING PATIENTS THE BEST QUALITY OF LIFE; MOBILITY, FREEDOM AND THE HEALTH TO GO OUT AND EXPERIENCE LIFE LIKE WHEN THEY WERE FEELING YOUNGER IS THE SINGULAR FOCUS THAT DRIVES EVERYTHING THAT WE DO.
XCIR is an epigentic modulator effective for all tissue cell types. XCIR contributes to the homeostasis of normal tissues and organs as well as to tissue regeneration. Functions of XCIR and its effects on stem cells include its activity as cofactor of Fe+2/αKG dioxygenases, which regulate the epigenetic signatures, the redox status, and extracellular matrix (ECM) composition.
Acting in collagen prolyl hydroxylases in the endoplasmic reticulum, XCIR regulates ECM/collagen homeostasis and plays a key role in the differentiation of mesenchymal stem cells towards ALL tissue types including cadiomyocytes, fibroblasts, osteoblasts, chondrocytes and tendons. In the stem cell nucleus, XCIR enhances the activity of DNA and histone demethylases, pushing all stem cell tissue types towards the naive pluripotent state and improving somatic cell reprogramming.
Transcription factors and signaling molecules are well-known regulators of stem cell identity and behavior; however, increasing evidence indicates that environmental cues contribute to this complex network of stimuli, acting as crucial determinants of stem cell fate. XCIR has gained growing interest for its multiple functions and mechanisms of action using free floating cyclic ladder polyether biotechnology that creates structure for cell attraction to form a biologic, nano, self assembling matrix.
This broad spectrum of actions of XCIR highlights its relevance as a platform for all areas in regenerative medicine.
WHAT MAKES XCIR UNIQUE ?
ONE ELEGANT PLATFORM FOR TISSUE REGENERATION
NANO SELF ASSEMBLING MATRIX
Providing doctors and researchers the tools to get stem cell based, regenerative tissue therapies
into mainstream medicine
on demand, in a safe and affordable way
The first and only molecule that offers tight control of stem cell microenvironment, including cell organization, metabolic and mechanical environments. XCIR enhances epigenetic modifications, including DNA and histone demethylation and promotes cell re-programming. XCIR is an effective approach to regulate endogenous ROS generation for better quantification of ROS towards the accurate control of stem cell fate.
Self Assembling Matrix
Overcome barriers in engineering bio-identical formed tissue. Ocis has developed a breakthrough for advancing molecular nanotechnology
to make patented cyclic molecules, to self assemble into bio-identical matrix like Leggo's. The cyclic molecules are free floating in vivo or invitro for cells to connect through biological forces. Any cell type can carry out it's specific genetic instruction for bio-identical tissue type in mechanical strength and elasticity.
XCIR modulates various components of the inflammatory FAK-ERK-MCP-1 pathway and scar formation was attenuated as in embryonic scarless healing. XCIR modulated fibroblast gene expression, causing increased proliferation and migration comparable to embryonic healing. Moreover, proteome analysis of cultured fibroblasts revealed XCIR modulates
comparable patterns of protein expression as occurs in fetal fibroblasts.